GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2273 | 1 | rs6827617 | chr4:76916146 | NAAA | chr4:76831809-76862166:- | -0.37 | -6.07 | 3.06E-9 | Longevity |
| BLCA | cis | rs7714584 | 1 | rs6862814 | chr5:150245259 | LOC134466 | chr5:150310000-150326146:- | 0.43 | 5.77 | 1.66E-8 | Crohn's disease |
| BLCA | cis | rs568617 | 1 | rs687672 | chr11:65649984 | CTSW | chr11:65647284-65651212:+ | 0.59 | 8.99 | 1.14E-17 | Crohn's disease |
| BLCA | cis | rs568617 | 1 | rs687672 | chr11:65649984 | SNX32 | chr11:65601410-65621170:+ | -0.34 | -4.75 | 2.93E-6 | Crohn's disease |
| BLCA | cis | rs10461617 | 1 | rs6885541 | chr5:56110857 | C5orf35 | chr5:56205103-56213010:+ | 0.72 | 10.68 | 1.81E-23 | Type 2 diabetes |
| BLCA | cis | rs9369898 | 1 | rs6902429 | chr6:49393500 | CENPQ | chr6:49431096-49460820:+ | -0.4 | -8.67 | 1.24E-16 | Homocysteine levels |
| BLCA | cis | rs9371538 | 1 | rs6904133 | chr6:151881805 | C6orf97 | chr6:151815175-151942327:+ | 0.29 | 4.46 | 1.09E-5 | Bone mineral density (spine) |
| BLCA | cis | rs6910233 | 1 | rs6910233 | chr6:33534726 | BAK1 | chr6:33540324-33548070:- | 0.2 | 4.79 | 2.4E-6 | Chagas cardiomyopathy in Tripanosoma cruzi seropositivity |
| BLCA | cis | rs1577917 | 1 | rs6914463 | chr6:86653415 | SNHG5 | chr6:86386726-86388451:- | -0.55 | -10.04 | 3.3E-21 | Response to antipsychotic treatment |
| BLCA | cis | rs9369898 | 1 | rs6915187 | chr6:49423547 | CENPQ | chr6:49431096-49460820:+ | -0.41 | -8.83 | 3.75E-17 | Homocysteine levels |
| BLCA | cis | rs9369898 | 1 | rs6916888 | chr6:49383804 | CENPQ | chr6:49431096-49460820:+ | -0.4 | -8.67 | 1.24E-16 | Homocysteine levels |
| BLCA | cis | rs9369898 | 1 | rs6918347 | chr6:49406348 | CENPQ | chr6:49431096-49460820:+ | -0.39 | -8.57 | 2.55E-16 | Homocysteine levels |
| BLCA | cis | rs6918586 | 1 | rs6918586 | chr6:26097384 | BTN3A2 | chr6:26365398-26378546:+ | -0.22 | -4.52 | 8.19E-6 | Schizophrenia |
| BLCA | cis | rs9473555 | 1 | rs6923124 | chr6:49419864 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.47 | 8.32E-8 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs6923124 | chr6:49419864 | MUT | chr6:49398994-49431031:- | 0.29 | 5.76 | 1.68E-8 | Folate pathway vitamin levels |